北京大学生命科学学院博士生导师简介：汤富酬

　　考博考生生准备要参加博士研究生考试时，必须要先确定准备攻读博士的相关专业，然后选择该专业有招生需求的学校，接下来应该联系博士生导师，只有当博士生导师同意考生报考，考博生才可以报考。所以提前了解博士生导师的学术文章及联系方式很重要，新东方在线特整理了各招收博士院校博导的简介及联系方式供考博生参考。

汤富酬

　　邮　　箱：tangfuchou(AT)pku.edu.cn

　　职　　称：研究员

　　研究员,博士生导师

　　联系电话：62755246

　　地　　址：：海淀区颐和园路5号,北京,中国

　　邮　　编：：100871

　　个人简历科研领域描述 具有自我更新能力和分化潜能的干细胞是哺乳动物胚胎发育过程中以及成体中的关键种类的细胞，对各种干细胞进行深入研究是理解哺乳动物发育、生长机制的关键，也是将干细胞应用于临床再生医学、治疗人类疾病的前提。本实验室主要围绕人类早期胚胎发育、研究多能干细胞的自我更新能力和多能性调控的分子机理，特别是表观遗传学调控机理，以及相关的原始生殖细胞发育过程中的表观遗传学重编程机理。利用我们发展的单细胞功能基因组学分析技术(单细胞 RNA-Seq 转录组分析技术、单细胞 DNA甲基化组测序技术等)，以及少量细胞染色体免疫共沉淀-高通量测序技术、单细胞基因组测序技术、小鼠胚胎显微操作技术和胚胎干细胞体外定向分化等技术在单细胞和单碱基分辨率深入分析人类早期胚胎以及多能性干细胞中基因表达网络的表观遗传学调控机理。代表性论文1. Guo F, Yan L, Guo H, Li L, Hu B, Zhao Y, Yong J, Hu Y, Wang X, Wei Y, Wang W, Li R, Yan J, Zhi X, Zhang Y, Jin H, Zhang W, Hou Y, Zhu P, Li J, Zhang L, Liu S, Ren Y, Zhu X, Wen L, Gao YQ, Tang F*, Qiao J*. The transcriptome and DNA methylome landscapes of human primordial germ cells. Cell, 2015, 161: 1437-1452 (*: Co-corresponding authors).

　　2. Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang F*, Liu GH*, Belmonte JC*. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science, 2015, 348: 1160-1163 (*: Co-corresponding authors).

　　3. Wen L*, Tang F* , Charting a Map through the Cellular Reprogramming Landscape. Cell Stem Cell, 2015 , 16: 215-216 (Preview) (*: Co-corresponding authors).

　　4. Guo H, Zhu P, Guo F, Li X, Wu X, Fan X, Wen L*, Tang F*. Profiling DNA methylome landscapes of mammalian cells with single-cell reduced-representation bisulfite sequencing. Nature Protocols, 2015, 10: 645-659 (*: Co-corresponding authors).

　　5. Wu Y, Zhou H, Fan X, Zhang Y, Zhang M, Wang Y, Xie Z, Bai M, Yin Q, Liang D, Tang W, Liao J, Zhou C, Liu W, Zhu P, Guo H, Pan H, Wu C, Shi H, Wu L* , Tang F*, Li J,*. Correction of a Genetic Disease by CRISPR-Cas9-Mediated Gene Editing in Mouse Spermatogonial Stem Cells. Cell Research , 2015 , 25: 67-79 (*: Co-corresponding authors).

　　6. Shen J, Jiang D, Fu Y, Wu X, Guo H, Feng B, Pang Y, Streets AM, Tang F*, Huang Y*. H3K4me3 epigenomic landscape derived from ChIP-Seq of 1 000 mouse early embryonic cells. Cell Research, 2015, 25: 143-147 (*: Co-corresponding authors).

　　7. Guo F, Li X, Liang D, Li T, Zhu P, Guo H, Wu X, Wen L, Gu TP, Hu B, Walsh CP, Li J*, Tang F*, Xu GL*. Active and Passive Demethylation of Male and Female Pronuclear DNA in the Mammalian Zygote. Cell Stem Cell, 2014, 15: 447-458 (*: Co-corresponding authors).

　　8. Guo H, Zhu P, Yan L, Li R, Hu B, Lian Y, Yan J, Ren X, Lin S, Li J, Jin X, Shi X, Liu P, Wang X, Wang W, Wei Y, Li X, Guo F, Wu X, Fan X, Yong J, Wen L, Xie SX, Tang F*, Qiao J*. The DNA methylation landscape of human early embryos. Nature, 2014, 511: 606-610 (*: Co-corresponding authors).

　　9. Wen L, Tang F*, Reconstructing Complex Tissues from Single-Cell Analyses. Cell, 2014, 157: 771-773 (*: Corresponding author).

　　10. Wen L, Li X, Yan L, Tan Y, Li R, Zhao Y, Wang Y, Xie J, Zhang Y, Song C, Yu M, Liu X, Zhu P, Li X, Hou Y, Guo H, Wu X, He C*, Li R*, Tang F*, Qiao J*. Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain. Genome Biology, 2014, 15: R49 (*: Co-corresponding authors).

　　11. Streets AM, Zhang X, Cao C, Pang Y, Wu X, Xiong L, Yang L, Fu Y, Zhao L*, Tang F*, Huang Y*. Microfluidic single-cell whole-transcriptome sequencing. Proc Natl Acad Sci U S A, 2014, 111: 7048-7053 (*: Co-corresponding authors).

　　12. Hou Y, Fan W, Yan L, Li R, Lian Y, Huang J, Li J, Xu L, Tang F*, Xie XS*, Qiao J*. Genome Analyses of Single Human Oocytes. Cell, 2013, 155: 1492-1506 (*: Co-corresponding authors).

　　13. Guo H, Zhu P, Wu X, Li X, Wen L, Tang F*. Single-cell methylome landscapes of mouse embryonic stem cells and early embryos analyzed using reduced representation bisulfite sequencing. Genome Research, 2013, 23: 2126-2135 (*: Corresponding author).

　　14. Yan L, Yang M, Guo H, Yang L, Wu J, Li R, Liu P, Lian Y, Zheng X, Yan J, Huang J, Li M, Wu X, Wen L, Lao K, Li R*, Qiao J*, Tang F*. Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells. Nature Structural & Molecular Biology, 2013, 20: 1131-1139 (*: Co-corresponding authors).

　　15. Gan H, Wen L, Liao S, Lin X, Ma T, Liu J, Song CX, Wang M, He C, Han C*, Tang F*. Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis. Nature Communications, 2013, 4: 1995 (*: Co-corresponding authors).

　　16. Hu X, Zhang L, Mao SQ, Li Z, Chen J, Zhang RR, Wu HP, Gao J, Guo F, Liu W, Xu GF, Dai HQ, Shi YG, Li X, Hu B, Tang F., Pei D, Xu GL. Tet and TDG Mediate DNA Demethylation Essential for Mesenchymal-to-Epithelial Transition in Somatic Cell Reprogramming. Cell Stem Cell, 2014, 14: 512-522.

　　17. Grabole N, Tischler J, Hackett JA, Kim S, Tang F., Leitch HG, Magnúsdóttir E, Surani MA. Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation. EMBO Reports, 2013, 14: 629-637.

　　18. Zhang RR, Cui QY, Murai K, Lim YC, Smith ZD, Jin S, Ye P, Rosa L, Lee YK, Wu HP, Liu W, Xu ZM, Yang L, Ding YQ, Tang F. Meissner A, Ding C, Shi Y, Xu GL. Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition. Cell Stem Cell, 2013, 13: 237-245.

　　19. Magnúsdóttir E, Dietmann S, Murakami K, Günesdogan U, Tang F., Bao S, Diamanti E, Lao K, Gottgens B, Surani MA. A tripartite transcription factor network regulates primordial germ cell specification in mice. Nature Cell Biology, 2013, 15: 905-915.

　　20. Lu S, Zong C, Fan W, Yang M, Li J, Chapman AR, Zhu P, Hu X, Xu L, Yan L, Bai F, Qiao J, Tang F., Li R, Xie XS. Probing meiotic recombination and aneuploidy of single sperm cells by whole-genome sequencing, Science, 2012, 338: 1627-1630.

　　21. Bao S, Leitch HG, Gillich A, Nichols J, Tang F., Kim S, Lee C, Zwaka T, Li X, Surani MA, The germ cell determinant blimp1 is not required for derivation of pluripotent stem cells. Cell Stem Cell, 2012, 11: 110-117.

　　22. Tang F, Lao K, Surani MA. Development and applications of single-cell transcriptome analysis. Nature Methods, 2011, 8: S6-S11 (Review).

　　23. Tang F, Barbacioru C, Bao S, Lee C, Nordman E, Wang X, Lao K, Surani MA. Tracing the Derivation of Embryonic Stem Cells from the Inner Cell Mass by Single-Cell RNA-Seq Analysis. Cell Stem Cell, 2010, 6: 468 – 478.

　　24. Tang F*. Small RNAs in mammalian germline: tiny for immortal. Differentiation, 2010, 79: 141-146 (Review) (*: Corresponding author)

　　25. Tang F, Barbacioru C, Nordman E, Li B, Xu N, Bashkirov VI, Lao K, Surani MA. RNA-Seq analysis to capture the transcriptome landscape of a single cell. Nature Protocols , 2010, 5: 516-535.

　　26. Bao S*, Tang F*, Li X, Hayashi K, Gillich A, Lao K, Surani MA. Epigenetic reversion of postimplantation epiblast to pluripotent embryonic stem cells. Nature, 2009, 461: 1292-1295 (*: co-first authors).

　　27. Tang F*, Barbacioru C*, Wang Y, Nordman E, Lee C, Xu N, Wang X, Bodeau J, Tuch BB, Siddiqui A, Lao K, Surani MA. mRNA-Seq whole transcriptome analysis of a single cell. Nature Methods, 2009, 6: 377-382 (*: co-first authors).

　　28. Hayashi K, Lopes SM, Tang F, Surani MA. Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states. Cell Stem Cell, 2008, 3: 391-401.

　　29. Tang F*, Kaneda M*, O'Carroll D, Hajkova P, Barton SC, Sun YA, Lee C, Tarakhovsky A, Lao K, Surani MA. Maternal microRNAs are essential for mouse zygotic development. Genes & Development, 2007, 21: 644-648 (*: co-first authors).

　　30. Tang F, Hajkova P, Barton SC, O'Carroll D, Lee C, Lao K, Surani MA. 220-plex microRNA expression profile of a single cell. Nature Protocols, 2006, 1: 1154-1159.

　　31. Tang F, Hajkova P, Barton SC, Lao K, Surani MA. MicroRNA expression profiling of single whole embryonic stem cells. Nucleic Acids Research, 2006, 34: e9.