韩福社：中国科学院长春应用化学研究所博士生导师

韩福社，男，中国科学院长春应用化学研究所研究员，博士生导师，中科院“百人计划”获得者。主要研究方向为天然物合成、药物合成、不对称催化、过渡金属催化的偶联方法学等。　迄今在Chem. Soc. Rev.、J. Am. Chem. Soc.、Adv. Mater.、Chem. Commun.、Org. Lett.、Chem. Eur. J.、Adv. Synth. Catal.、ChemCatChem等发表文章60余篇，其中影响因子大于5的30余篇；申请专利13项，其中已授权7项。吉林省化学会有机化学专业委员会副主任；吉林省药学会药物化学专业委员会委员。

主要学习工作经历：

1989.9-1993.7 重庆大学化工学院精细化工专业，本科。期间获香港社会福利基金会华新奖学金。

1993.9-1996.7 大连理工大学化工学院有机化学系，硕士研究生；1996年获辽宁省教育厅科技进步二等奖。

1996.9-1999.9 中科院长春应化所有机和高分子室，博士研究生；中科院优秀博士毕业生，获伟华科技一等奖学金。

1999.10-2001.7 中科院上海有机所生命有机室博士后 （马大为教授组）。

2001.8-2003.3 日本Ehime 大学工学部应用化学科博士后 （Yutaka Watanabe 教授）；日本文部省Venture Business Laboratory (VBL) 特别研究员基金。

2003.4-2006.3 东京大学药学部天然物合成化学科，科学技振兴机构（JST）研究员（Tohru Fukuyama 教授）；日本科学技术振兴机构（JST） PRESTO研究员基金。

2006.4-2008.7 日本国立物质材料研究机构，有机纳米中心，博士研究员（合作者：Dirk G. Kurth博士，德国Max-Planck 研究所；Masayoshi Higuchi 博士，物质材料研究机构）；

2008.8-今, 中科院长春应用化学研究所，研究员/博导/“百人计划”获得者。

主要承担项目：

1） 国家自然科学基金面上项目

2） 中科院“百人计划”项目

3） 中科院天然产物合成化学重点实验室开放课题基金

4） 生命有机化学国家重点实验室开放课题基金

5） 精细化工国家重点实验室开放课题基金

代表性论文（第一作者或通讯联系人）：

1) F. Han,＊ “Transition-Metal-Catalyzed Suzuki-Miyaura Cross-Coupling Reactions: A Remarkable Advance from Palladium to Nickel Catalysts”, Chem. Soc. Rev., 2013, 42, 5270. (Invited review). (IF = 30.425)

2) F. Han, M. Higuchi, D. G. Kurth, “Metallo-Supramolecular Polymers Based on Functionalized Bis-terpyridines as Novel Electrochromic Materials” Adv. Mater., 2007, 19,3928. (IF = 15.409)

3) Z.-J. Du, J. Guan, G.-J. Wu, P. Xu, L.-X. Gao, F.-S. Han,＊ “Palladium-Catalyzed Enantioselective Synthesis of P-Stereogenic Phosphinamides via Desymmetric C–H Arylation”, J. Am. Chem. Soc., 2015, 137, 632. (IF = 11.444)

4) F. Han, M. Higuchi, D. G. Kurth, “Metallo-Supramolecular Polyelectrolytes Self-assembled from Various Pyridine Ring Substituted Bis-terpyridines and Metal Ions: Photophysical, Electrochemical and Electrochromic Properties” J. Am. Chem. Soc., 2008, 130, 2073. (IF = 11.444)

5) X. Zhong, Y. Li, W.-X. Zhang, J. Zhang, S.-X. Wang, F.-S. Han,＊ “Formal [3+3] Cyclization of Indol-2-yl Carbinol with Aza-Diene and the Subsequent Oxidative Ring Expansion Reaction for the Synthesis of Indole Azepinones”, Chem. Commun., 2014, 50, 11181. (IF = 6.718)

6) S. Qi, C.-Y. Liu, J.-Y. Ding, F.-S. Han,＊ “Chiral Phosphoramide-Catalyzed Enantioselective Synthesis of 2,3’-Diindoylarylmethanes from Indol-2-yl Carbinol and Indole”, Chem. Commun., 2014, 50, 8605. (IF = 6.718)

7) Y.-L. Zhao, G.-J. Wu, F. Han＊, “Ni-Catalyzed Construction of C–P Bond from Electron-deficient Phenols via the in situ Aryl C–O Activation by PyBroP”, Chem. Commun., 2012, 48, 5868. (IF = 6.718)

8) Y. Li, L.-X. Gao, F. Han＊, “Efficient Synthesis of 2,5-Disubstituted Tetrazoles via the Cu2O-Catalyzed Aerobic Oxidative Direct Cross-coupling of N-H Free Tetrazoles with Boronic Acids”, Chem. Commun., 2012, 48, 2719. (IF = 6.718)

9) S.-M. Li, J. Huang, G.-J. Chen, F. Han＊, “PdCl2(dppf)-Catalyzed in situ Coupling of 2-Hydroxypyridines with Aryl Boronic Acids Mediated by PyBroP and the one-pot Chemo- and Regioselective Construction of two Distinct Aryl-Aryl Bonds”, Chem. Commun., 2011, 47, 12840. (IF = 6.718)

10) F.-Q. Yuan, L.-X. Gao, F. Han＊, “PdCl2-Catalyzed Efficient Allylation and Benzylation of Heteroarenes under Ligand, Base/Acid, and Additive-Free Conditions”, Chem. Commun., 2011, 47, 5289. (IF = 6.718)

11) F. Han, H. Tokuyama, T. Fukuyama, “Design and Synthesis of Thiazoline-Thiazole Hybrid Macrocycles Possessing Strong Affinity to Pb2+ and Cd2+” Chem. Comm., 2007, 3444. (IF = 6.718)

12) F. Han, H. Osajima, M. Cheung, H. Tokuyama, and T. Fukuyama, “Synthesis of Chiral Cyclic Oligothiazolines: A Novel Structural Motif for a Macrocyclic Molecule”, Chem. Comm. 2006, 1757-1759. (IF = 6.718)

13) F. Han, M. Higuchi, T. Ikeda, Y. Negishi, T. Tsukuda, D. G. Kurth, “Luminescence Properties of Metallo-supramolecular Coordination Polymers Assembled from Pyridine Ring Functionalized Ditopic Bis-terpyridine and Ru(II) ions” J. Mater. Chem., 2008, 18, 4555. (IF = 6.626)

14) Z. Xue, Y. Li, J. Zhang, F.-S. Han,＊ “Synthetic Study Toward the Misassigned (±)-Tronoharine”, Org. Lett., 2015, 17, 720. (IF = 6.324)

15) H. Xu, P.-T. Liu, Y.-H. Li, F.-S. Han,＊ “Copper-Mediated Direct Aryl C–H Cyanation with Azobisisobutyro-nitrile via a Free-radical Pathway”, Org. Lett., 2013, 15, 3354. (IF = 6.324)

16) F.-Q. Yuan, F. Han＊, “Synthesis of Densely Substituted ,,,-Dienones via the PdII-Catalyzed Allylation, H-Migration, and Aerobic Oxidative -Hydride Elimination Cascade”, Org. Lett., 2012, 14, 1218. (IF = 6.324)

17) F. Han, M. Higuchi, D. Kurth, “Diverse Synthesis of Novel Bisterpyridines via Suzuki-Type Cross-Coupling” Org. Lett., 2007, 9, 559-562. (IF = 6.324)

18) J. Guan, G.-J.Wu, F.-S. Han,＊ “Pd(II)-Catalyzed Mild C–H ortho Arylation and Intramolecular Amination Oriented by Phosphinamide Group”, Chem. Eur. J., 2014, 20, 3301. (IF = 5.696)

19) C.-Y. Liu, Y. Li, J.-Y. Ding, D.-W. Dong, F.-S. Han,＊ “The Development of Copper-Catalyzed Aerobic Oxidative Coupling of H-Tetrazoles with Boronic Acids and an Insight into the Reaction Mechanism”, Chem. Eur. J., 2014, 20, 2373. (IF = 5.696)

20) X. Zhong, Y. Li, F. Han＊, “Al-Catalyzed Facile Construction of Quaternary C–C Bonds via the Allylic Substitution of tertiary Alcohols: A Concise Formal Synthesis of (±)-Mersicarpine”, Chem. Eur. J., 2012, 18, 9784. (IF = 5.696)

21) Y.-L. Zhao, G.-J. Wu, Y. Li, L.-X. Gao, F. Han＊, “Ni(dppp)-Catalyzed Cross-coupling of Aryl Halides with Dialkylphosphite, Diphenylphosphine oxide, and Diphenylphosphine”, Chem. Eur. J., 2012, 18, 9622. (IF = 5.696)

22) G. J. Chen, J. Huang, L. X. Gao, F. Han＊, “Ni-Catalyzed Cross-Coupling of Phenols and Aryl Boronic Acids via an in situ Phenol Activation Mediated by PyBrOP”, Chem. Eur. J., 2011, 17, 4038. (IF = 5.696)

23) Y. Li, L. X. Gao, F. Han＊, “Reliable and Diverse Synthesis of Aryl Azides via Copper-Catalyzed Coupling of Boronic Acids/Esters with TMSN3”, Chem. Eur. J., 2010, 16, 7969. (IF = 5.696)

24) Y. L. Zhao, Y. Li, Y. Li, L. X. Gao, F. Han＊, “Aryl Phosphoramides: Useful Electrophiles for SuzukiMiyaura Coupling Catalyzed by NiCl2/dppp System”, Chem. Eur. J., 2010, 16, 4991. (IF = 5.696)

25) F. Han, H. Osajima, M. Cheung, H. Tokuyama, and T. Fukuyama, “Novel Structural Motifs Consisting of Chiral Thiazolines: Synthesis, Molecular Recognition, and Anticancer Activity” Chem. Eur. J. 2007, 13,3026 (Selected as inside cover page). (IF = 5.696)

26) F.-Q. Yuan, F. Han＊, “Iron-Catalyzed Direct Synthesis of Densely Substituted Benzofurans and Naphthopyrans from Phenolic Compounds and Propargylic Alcohols” Adv. Synth. Catal., 2013, 355, 537. (IF = 5.542)

27) Y.-L. Zhao, Y. Li, S.-M. Li, Y.-G. Zhou, F.-Y. Sun, L.-X. Gao, F.-S. Han＊, “A Highly Practical and Reliable Nickel Catalyst for Suzuki-Miyaura Coupling of Aryl Halides” Adv. Synth. Catal., 2011, 353, 1543. (IF = 5.542)

28) H. Gao, Y. Li, Y. G. Zhou, F. Han,＊ Y. J. Lin＊, “Highly Efficient Suzuki-Miyaura Coupling of Aryl Tosylates and Mesylates Catalyzed by Stable, Cost-effective [1,3-Bis(diphenylphosphino)propane]nickel(II) Chloride {Ni(dppp)Cl2} with only 1 mol ％ Loading”, Adv. Synth. Catal., 2011, 353, 309. (IF = 5.542)

29) Z.-J. Du, L.-X. Gao, Y.-J. Lin, F.-S. Han,＊ “Cu-Mediated Direct Aryl C–H Halogenation: a Strategy to Control Mono- and Di-Selectivity”, ChemCatChem, 2014, 6, 123. (IF = 5.044)

30) G.-J. Wu, J. Guan, F.-S. Han,＊ Y.-L. Zhao,＊ “Palladium-Catalyzed Silver-Mediated α-Arylation of Acetic acid: A New Approach for the α-Arylation of Carbonyl Compounds”, ChemCatChem, 2014, 6, 1589. (IF = 5.044)

授权专利 （第一发明人）：

1）韩福社，高连勋，赵玉龙，一种联芳烃类和双烯烃类化合物的制备方法，2012.9，中国，ZL 200910260220.7

2)　韩福社，李水明，孙凤一，一种氨基联苯的制备方法，2013.12，中国，ZL 201010604776.6

3) 韩福社，高连勋，赵玉龙，一种镍类催化剂在铃木偶联反应中的应用，2013.11，中国，ZL 201010161977.3

4）F. Han, M. Higuchi, D. G. Kurth, “Synthesis of symmetrical or asymmetrical bis(terpyridine) compound used for polymer used as electrochromic material and display material such as electronic paper, involves carrying out coupling reaction of terpyridine compound”, JP 2008162979-A.

5）F. Han, M. Higuchi, D. G. Kurth, “Manufacture of bis(terpyridine) compound for electro-chromic material, electronic paper for display devices and electrochromic multicolorization, involves performing coupling reaction of terpyridine compounds and boron compound”, JP2008162967-A.

6）F. Han, M. Higuchi, D. G. Kurth, “Synthesis of spacer introduction bis(terpyridine) compound used as electrochromic material for display device such as electronic paper, involves coupling two or more terpyridine compound with boron compound”, JP2008162976-A.