北京大学分子医学研究所博士生导师简介：顾雨春

　　学会会员:

　　英国皇家生理学会会员

　　剑桥大学 St. Edmond's College fellow

　　代表论文：

　　1. Wu J, Wang S, Gu Y, Zhang S, Publicover SJ, Franklin-Tong VE.(2011) Self-incompatibility in papaver rhoeas activates nonspecific cation conductance permeable to Ca2+ and K+. Plant Physiol.155(2):963-73.

　　2. M. Malboubi, Y. Guand K. Jiang (2011)Characterization of surface properties of glass micropipettes using SEM stereoscopic technique. Microelectronic Engineering (in press)

　　3. C Tang, H Zhang, S Wang, J Wu, Y Gu (2010) A role for receptor operated Ca(2+) entry in human pulmonary artery smooth muscle cells in response to hypoxia. Physiol Res 59(6)：909-18.

　　4. M Malboubi, Y Gu, K Jiang (2010) Experimental and stimulation study of the effect of pipette roughness on giga seal formation in patch clamping. Microelectronic Engineering 87:778-781.

　　5. C Tang, H Zhang, S Wang, J Wu, Y Gu (2009) Difference in regulation mechanism of ENaC by aldosterone and glucocorticords. J of Health (on line)

　　6. Malboubi M, Ostadi H., Wang S., Gu Y. and Jiang K. (2009) Effects of the surface morphology of pipette tip on Giga-seal formation. Engineering Letters 17 (4): 281-285.

　　7. Malboubi M, Ostadi H, Wang S, Gu Y and Jiang K (2009) The Effect of Pipette Tip Roughness on Giga-seal Formation, Proceedings of the World Congress on Engineering Vol II, pp: 1849-1852.

　　8. M Turvey, Y Gu (2009) The effects of extracellular nucleotides on [Ca2+]I signalling in human derived renal proximal tubular cell line (HKC-8). J Cell Biochem 109(1):132-9.

　　9. Su Wang, S. Publicover, Y Gu (2009) An oxygen-sensitive mechanism in regulation of ENaC. PNAS. 106(8): 2957-62.

　　10. J Wang, R Zhi, Y Gu, H, Ma (2009) Cyclosporine stimulates the renal epithelial ENaC by elevating cholesterol. Am J Physiol， Renal Physiol 296(2):F284-90.

　　11. Su Wang, Fei Meng, Jingyuan Xu, Yuchun Gu. (2008) Effects of lipids on ENaC activity in cultured mouse cortical collecting duct cells. J Membrane Biology 227(2): 77-85

　　12. Yuchun Gu. (2008) Effects of [Ca2+]I and pH on ENaC activity from cultured mouse cortical collecing ducts. J Experimental Biology 211: 3167-73.

　　13. Su Wang, Fei Meng, Sindu Mohan, Bipin Champaneri, Yuchun Gu. (2009) Functional EnaC channels expressed in endothelial cells: a new candidate in endothelial cells to mediate shear force. Microcirculation 16(3):276-87

　　14. Meng F, To WK, Gu Y. (2008) Role of TRP channels and NCX in mediating hypoxia-induced [Ca(2+)](i) elevation in PC12 cells. Respir Physiol Neurobiol. 164(3):386-93.

　　15. Meng F, To WK, Gu Y. (2008) Inhibitory effect of arachidonic acid on hypoxia-induced [Ca2+]I elevation in human pulmonary artery smooth muscle cells and PC12 cells. Respir Physiol Neurobiol. Jun 30;162(1):18-23

　　16. Yuchun Gu (2008) Effect of [Cl-]i on ENaC activities from M1 cells. J Cell Phyisol 216(2):453-457

　　17. Su Wang, Yuchun Gu. (2008) Cation channels in human embryonic kidney cells mediating calcium entry in response to extracellular low glucose. Biochem Biophys Res Commun. 365(4):704-10.

　　18. Fei Meng, Wilson To, Jackson Kirkmanbrown, Prem Kumar, Yuchun Gu. (2007) Calcium oscillation induced by ATP in human umbilical cord smooth muscle cells. J Cell Phyisol May 3; Oct;213(1):79-87.

　　19. J Maria, J Kirkmanbrown, C Barratt, Y Gu, S Publicover.(2007) Co-localization of ion channels in human sperm. (submitted) J Cell Phyisol Dec;213(3):801-8.

　　20. Gu Y, Oberwinkler J, Postma M, Wang, Montell CM, Hardie RC (2005) Ca2+ dependent of PLC signalling in Drosophila photoreceptors Curr Biol. 15, 1228-1234

　　21. Tao wang, Hong Xu, Johannes Oberwinkelr, Yuchun Gu, Roger Hardie and Craig Montell. (2005) Dependence on the Na+/Ca2+ exchanger, CalX, for light-activation, adaptation and cell survival. Neuron 45(3):367-378.

　　22. Hardie RC, Gu Y, Martin F, Sweeney S, & Raghu P. (2004) In vivo basal and light induced PLC activity in Drosophila photoreceptors measured with genetically targeted PIP2 sensitive ion channels (Kir2.1). J Biol Chem 279, 47773-47782

　　23. Foreman MA, Gu Y, Howl JD, Jones S, Publicover SJ. (2005) Group III metabotropic glutamate receptor activation inhibits Ca(2+) influx and nitric oxide synthase activity in bone marrow stromal cells. J Cell Physiol. Mar 29; 204, 704-713

　　24. Y Gu. J C Kirkman-Brown, Y Korchev, CLR Barratt, SJ Publicover. (2004) Patch clamping recording from human spermatozoa – expression of very-high conductance multi-state K+ channels. Devl Biol. 274:308-317.

　　25. Jagannathan S, Gu Y, Punt EL, Arnoult C, Sakkas D, Barratt CL, Publicover SJ. (2002) Identification and Localisation of T-Type Voltage Operated Calcium Channel Subunits in Human Male Germ Cells – Expression of Multiple Isoforms. J Biol Chem. 277(10): 8449-56

　　26. Yuchun Gu, Julia Gorelik, Hilmar A. Spohr, Andrew Shevchuk, Max J. Lab, Sian E. Harding, Igor Vodyanoy, David Klenerman and Yuri E. Korchev. (2002) High Resolution Scanning Patch-Clamp: New Insight into Cell Function. FASEB J May; (front cover page). 16(7):748-50

　　27. Julia Gorelik, Yuchun Gu, Hilmar A. Spohr, Andrew Shevchuk, Max J. Lab, Sian E. Harding, A, Darszon, Igor Vodyanoy, David Klenerman and Yuri E. Korchev. (2002) Ion Channels in Small Cells and Subcellular Structures can be Studied with a Smart Patch-Clamp System. Biophys J. Dec; 83(6): 3296-303.

　　28. Zuzanna Siwy, Yuchun Gu, Hilmar A. Spohr, Dagmar Baur, Alexander Wolf-Reber, Reimar Spohr, Pavel Apel, Yuri E. Korchev. (2002) Rectification and Voltage Gating in Ion Currents in a Nanofabricated Pore.: Europhysics Letters. 60, , p. 349 – 355

　　29. Gu Y, Genever PG, Skerry TM, Publicover SJ. (2002) The NMDA type glutamate receptors expressed by primary rat osteoblasts have the same electrophysiological characteristics as neuronal receptors. Calcif Tissue Int. 70(3):194-203.

　　30. Gu Y, Preston MR, Magnay J, El Haj AJ, Publicover SJ.(2001) Hormonally-regulated expression of voltage-operated Ca(2+) channels in osteocytic (MLO-Y4) cells. Biochem Biophys Res Commun. 282(2):536-42.

　　31. Y, Gu., M. R. Preston., A.J. El Haj., J.D.Howl., and S.J. Publicover. (2001) Three Types of K+ Currents in Murine Osteocyte-Like Cells (MLO-Y4). Bone. 28: 29-37.

　　32. Y, Gu., S, Publicover. (2000) Expression of Functional Metabotropic Glutamate Receptors in Primary Cultured Rat Osteoblasts: Cross-Talk with N-Methyl-D-Aspartate Receptors. J Biol Chem. 275: 34252-34259.

　　33. Y, Gu., S, Publicover. (1999) Osteoblasts derived from load-bearing bones of the rat express both L- and T-like voltage-operated calcium channels and mRNA for alpha 1C, alpha 1D and alpha 1G subunits. Pflugers Arch. Sep;438(4):553-60.