赵燕芳(沈阳药科大学制药工程学院博士研究生导师)简介

赵燕芳，女，博士，教授，博士生导师。1995年毕业于河北医科大学药学院，获理学学士学位；1998年进入沈阳药科大学药物化学专业攻读硕士学位，2004年获沈阳药科大学药物化学专业博士学位，同年留校任教。2015年12月被聘为沈阳药科大学教授。目前主要的研究方向是为抗肿瘤和抗感染创新药物的研究。作为课题负责人，共主持纵向项目5项：包括国家自然基金青年科学基金2项；国家重大新药创制科技重大专项1项，辽宁省重大新药创制综合平台子课题1项以及省级项目3项和沈阳市科技项目2项。共申请发明专利23项，其中申请PCT 7项,获得授权4项。发表研究论文35篇，其中SCI收载20余篇。2015年被评为辽宁省第九批“百千万人才工程”百人层次人选。2015年被评为沈阳药科大学优秀研究生导师。

主持、参与的科研项目

1. 基于PI3K(β)/mTOR双靶标的2－双芳基脲嘧啶骨架类似物的设计合成及其抗肿瘤活性研究，国家自然科学基金青年基金项目，基金编号81573296（负责人）

2. 基于非 P-gp底物的含吲哚啉-2-酮结构的4-噻唑烷酮类衍生物的设计、合成及抗肿瘤活性研究，国家自然科学基金青年基金项目，基金编号81202405（负责人）

3. 新型抗乙肝病毒候选药物AG-376的研发，国家科技重大专项；项目批准号：2012ZX09103101-040（负责人）

4. PI3K/mTOR双重抑制剂的设计、合成及抗肿瘤活性研究，辽宁省教育厅高等学校杰出青年学者成长计划，基金编号LJQ2013106（负责人），

近年来发表的代表性论文或论著

1. LIU Zijian, HOU Yunlei1, ZHANG Guogang, XU Ning, MI Bin, GONG Ping, ZHAO Yanfang＊. Design, Synthesis and Antitumor Activity of Novel Indolin-2-one Derivatives Containing 4-Thiazolidinone Moiety. Chem. Res. Chin. Univ., 2015, 31(2), 235-243(通讯, IF=0.875)

2. Yanfang Zhao, Mingyan Jiang, Shunguang Zhou, Shasha Wu, Xiaolong Zhang, Longsheng Ma, Kai Zhang, Ping Gong＊. Design, synthesis and structureeactivity relationship of oxazolidinone derivatives containing novel S4 ligand as FXa inhibitors. European J of Med Chem, 2015, 96: 369-380(第一作者，IF=3.447)

3. Feng Wang, Zijian Liu, Jian Wang, Jun Tao, Ping Gong, Xue Bao, Yanfang Zhao＊, Yulin Wang＊. The interaction of 4-thiazolidinone derivatives containing indolin-2-one moiety with P-glycoprotein studied using K562 cell lines. European Journal of Medicinal Chemistry, 2015, 101: 126-132(双通讯, IF=3.447)

4. Mingze Qin, Tingting Wang, Boxuan Xu, Zonghui Ma, Nan Jiang, Hongbo Xie, Ping Gong＊, Yanfang Zhao＊. Novel hydrazone moiety-bearing aminopyrimidines as selective inhibitors of epidermal growth factor receptor T790M mutant. European J Med Chem, 2015(4): 115-126(双通讯, IF=3.447)

5. HOU Yunlei, WU Shasha, MA Longsheng, BAI Jinying, LIU Zijian and ZHAO Yanfang＊. Design, Synthesis and Antitumor Activity of Novel 6,7-Dimethoxyquinazoline Derivatives Containing Diaryl Urea Moiety.Chem. Res. Chinese Universities, 2015, 31(5), 766-773. (通讯，IF=0.875)

6. Zijian Liu, Shasha Wu, Yu Wang, Ruijuan Li, Jian Wang, Lihui Wang, Yanfang Zhao＊,Ping Gong＊. Design, synthesis and biological evaluation of novel thieno[3,2-d]pyrimidine derivatives possessing diaryl semicarbazone scaffolds as potent antitumor agents. European Journal of Medicinal Chemistry, 2014, 87: 782-793(双通讯, IF=3.432)

7. Di Wang, Yanfang Zhao, Zijian Liu, Hong Lei, Mei Dong, Ping Gong＊. In vitro and intracellular activity of 4-substituted piperazinyl phenyl oxazolidinone analogues against Mycobacterium tuberculosis. J Antimicrob Chemother，2014，12，1711-1714（并列第一作者，IF=5.338）

8. Qidong Tang, Guogang Zhang, XinmingDua, Wufu Zhu, Ruijuan Li, Huafang Lin, Pengcheng Li ,Maosheng Cheng, Ping Gong, Yanfang Zhao＊. Discovery of novel 6,7-disubstituted- 4-phenoxy quinoline derivatives bearing 5-(aminomethylene) pyrimidine-2,4,6-trione moiety as c-Met kinase inhibitors. Bioorganic & Medicinal Chemistry, 2014(22): 1236-1249. (通讯, IF=2.951)

9. Kaizhen Song, Junjie Ma, Xiao Wang, Ping Gong, Yanfang Zhao＊. Synthesis and Antitumor Activities of Novel 4-Morpholinothieno[3,2-d]pyrimidine Derivatives. Chem. Res. Chin. Univ., 2014, 30(1), 75-81. (通讯, IF=1.119)

10. Shunguang Zhou, Huimin Liao, Mingmei Liu, Guobing Feng, Baolin Fu, Ruijuan Li, Maosheng Cheng, Yanfang Zhao ＊, Ping Gong＊. Discovery and biological evaluation of novel 6,7-disubstituted-4-(2-fluorophenoxy)quinoline derivatives possessing 1,2,3-triazole-4-carbox amide moiety as c-Met kinase inhibitors. Bioorg Med Chem, 2014, 22: 6438–6452. (双通讯, IF=2.951)

11. Yan-Fang Zhao, Zi-Jian Liu, Xin Zhai, Dan-Dan Ge, Qiang Huang, Ping Gong.＊ Synthesis and in vitro antitumor activity of novel diaryl urea derivatives, Chin Chem Lett, 2013, 24: 386 –388.(第一作者, IF=1.210)

12. Wufu Zhu, Yajing Liu, Xin Zhai, Xiao Wang, Yan Zhu, Di Wu, Hongyu Zhou, Ping Gong, Yanfang Zhao＊. Design, synthesis and 3D-QSAR analysis of novel 2-hydrazinyl-4-morpholino thieno[3,2-d] pyrimidine derivatives as potential antitumor agents. European J Med Chem, 2012, 57, 162-175. (通讯, IF=3.346)

13. LijunXie, Xin Zhai, Lixiang Ren, Haiyan Meng, Chun Liu, Wufu Zhu, Yanfang Zhao＊. Design, synthesis and antitumor activity of novel artemisinin derivatives using hybrid approach. Chem. Pharm. Bull. 2011, 59(8) 984-990.(通讯, IF＝1.507)

14. Yanfang Zhao, Yajing Liu, Dong Chen, Zengquan Wei, Wenzhao Liu, Ping Gong. Synthesis and biological evaluation of 1H-benzimidazol-5-ols as potent HBV inhibitors. Bioorganic & Medicinal Chemistry Letters, 2010, 20, 7230–7233.(第一作者, IF＝2.650)

专利

1. 赵燕芳，宫平，刘亚婧，翟鑫，唐启东，刘子建，王昱. 新的4－噻唑烷酮类衍生物及其应用，申请号：201410681440.8，申请日：2014.11.24

2. 宫平，赵燕芳，刘亚婧，翟鑫，周顺光。含1,2,3-三氮唑的喹啉类化合物及其制备方法和应用，申请号：201410361065.9，申请日：2014.7.28，沈阳药科大学。

3. 宫平，赵燕芳，刘亚婧，翟鑫，周顺光，王昱，胡钢。含吡唑酮的喹啉类化合物及其制备方法和应用，申请号：201410154172.4，申请日：2014.4.17，沈阳药科大学。

4. 宫平，赵燕芳，刘亚婧，翟鑫，唐启东。含有杂环的5-羟基吲哚类衍生物及其用途，C N201210459223.5, 2012-11-15; PCT/CN2013/087136，2013.11.14

5. 宫平，赵燕芳，刘亚婧，翟鑫，唐启东。喹啉类化合物及其制备方法和应用，CN201310101651.5，2013.3.27

6. 宫平，赵燕芳，刘亚婧,翟鑫。新的喹啉类化合物及其用途，ZL201210436831.4，2012-11-5; PCT/CN2013/085848

7. 宫平，赵燕芳，刘亚婧，翟鑫，李赛，朱五福，秦铭泽。喹啉类及噌啉类化合物及其应用，ZL201210111920.1，2012-4-17

8．宫平，赵燕芳，刘亚婧，翟鑫，朱五福。嘧啶及三嗪类化合物的制备方法和应用，CN201110456642.9，2011-12-31