浙江大学医学院博士研究生导师简介：范伟民

　　21. Fukushima K, Tan JP, Korevaar PA, Yang YY, Pitera J, Nelson A, Maune H, Coady DJ, Frommer JE, Engler AC, Huang Y, Xu K, Ji Z, Qiao Y, Fan W, Li L, Wiradharma N, Meijer EW, Hedrick JL. Broad Spectrum Antimicrobial Supramolecular Assemblies with Distinctive Size and Shape. ACS Nano. 6:9191-9199, 2012 (IF 12.03)

　　22. Chang J and Fan W.* Endocrine Therapy Resistance: Current Status, Possible Mechanisms and Overcoming Strategies. Anticancer Agent Med Chem, 13:464-475,2013 (IF 2.86)

　　23. Li Y, Fukushima K, Coady DJ, Engler AC, Liu S, Huang Y, Cho JS, Guo Y, Miller LS, Tan JP, Ee PL, Fan W, Yang YY, Hedrick JL. Broad-Spectrum Antimicrobial and Biofilm-Disrupting Hydrogels: Stereocomplex-Driven Supramolecular Assemblies. Angew Chem Int Ed Engl. 52: 674-678, 2013 (IF 13.45)

　　24. Chen C, Wang Y, Goh SSL, Yang J, Lam DH, Chouhury Y, Tay FC, DS, Tan WK, Purwanti YI, Fan W and Wang S. Inhibition of neuronal nitric oxide synthase activity promotes migration of human induced pluripotent stem cell-derived neural stem cells towards cancer cells. J. Neurochem. 126:318-330, 2013 (IF 4.06)

　　25. Huang Y, Fu PF, Fan W.* Novel Targeted Therapies to overcome Trastuzumab Resistance in HER2-Overexpressing Metastatic Breast Cancer. Current Drug Targets, 14:889-898, 2013 (IF 3.56)

　　26. Jiang DH, Sui M, Zhong WY, Huang Y. and Fan W.* Different Administration Strategies with Paclitaxel Induce Distinct Phenotypes of Multidrug Resistance in Breast Cancer Cells. Cancer Letters, 335: 404-411, 2013 (IF 5.61)

　　27. Shahbazi M, Kwang TW,Purwanti YI, Fan W and Wang S. Inhibitory effects of neural stem cells derived from human embryonic stems on differention and function of monocyte-dendritic cells. J. Neurol Sciences, 330:65-93, 2013 (IF 2.35)

　　28. Huang H, Weaver A, Wu E, Gao H, Fan W, Wu M. Lipid based signaling modulates DNA repair response and survival against Klebsiella pneumoniae infection in host cells and in mice. Am J Respir Cell Mol Biol, 49:798-807,2103 (IF 5.13)

　　29. Zhu D, Lam DH, Purwanti Y, Goh S, Wu C, Zeng J, Fan W and Wang S. Systemic Delivery of Fusogenic Membrane Glycoprotein-Expressing Neural Stem Cells to Selectively Kill Tumor Cells, Mol Therapy, 21:1621-1630, 2013 (IF 7.04)

　　30. Han N, Yang YY, Wang S, Zheng S. and Fan W.* Polymer-based Cancer Nanotheranostics: Retrospectives of Multi-Functionalities and Pharmacokinetics. Current Drug Matab, 14:661-674, 2013 (IF 5.11)

　　31. Tay FC, Tan WK, Goh SL, Ramachandra CJ, Lau CH, Zhu H, Chen C, Du C, Phang RZ, Shahbazi M, Fan W., and Wang S* Targeted Transgene Insertion into the AAVS1 Locus Driven by Baculoviral Vector-mediated Zinc Finger Nuclease Expression in Human Induced Pluripotent Stem Cells. J. Gene Med, 15:384-395, 2013 (IF 3.08)

　　32. Phang RZ, Tay FCm Goh CA, Tan WK, Liang Q, Chen C, Du S, Li ZD, Kang JC, Zeng J, Fan W, Toh H and Wang S. Zinc Finger Nucleas-Expressing Baculovrial Vectors Mediate Target Genome Integration of Reprogramming Facotr Genes to Facilitate the Geration of Human Induced Puripotent Stem Cells. Stem Cells Trans Med. 2(12): 935-945, 2013 (IF 5.71)

　　33. Chin W,Yang C, Ng V, Huang Y, Cheng CJ,Tong Y, Coady DJ, Fan W, Hedrick J, Yang YY. Biodegradable Broad-Spectrum Antimicrobial Polycarbonates: Investigating the Role of Chemical Structure on Activity and Selectivity. Macromolecules. 46: 8797-8807, 2013 (IF 5.80]

　　34. Fukushima K, Liu S, Wu H, Engler A, Coady D, Maune H, Pitera J, Nelson A, Wiradharma N, Venkataraman S, Huang Y, Fan W, Ying J, Yang YY. Supramolecular High Aspect Ratio Assemblies with Strong Antifungal Activity. Nature Commun.,4:4881 Dec 9, 2013 [Epub Ahead of Print] (IF 11.47)

　　35. Ong Z, Cheng J, Huang Y, Xu K, Ji Z, Fan W. and Yang YY. Effect of Stereochemsitry, Chain Length and Sequence pattern on antimicrobial properties of Short Synthetic beta-sheet Forming Peptide Amphiphiles. Biomaterials,35:1315-1325, 2014 (IF 8.56)

　　36. Purwanti YI, Chen C, Lam DH, Wu C, Zeng J, Fan W, and Wang S. Antitumor Effects of CD40 Ligand-expressing Endothelial Progenitor Cells Derived from Human iPS Cells in a Metastatic Breast Cancer Model, Stem Cells Trans Med. 3:923-935, 2014 (IF 5.71)

　　37 Zhu HD, Lau C, Goh S, Liang Q, Chen C, Du S, Phang RZ,Tay FC, Tan WK, Li Z,Tay JC, Fan W and Wang S. Baculoviral Tranduction Facilitates TALEN-Mediated Targeted Transgene Integration and Cre/LoxP Cassette Exchange in Human-Induced pluripoten Stem Cells. Nucl Acid Res. Aug. 13, 2013 [Epub Ahead of Print] (IF 9.11)

　　38. Wu M, Gan CP, Li RP, Ye Y, Zhang S, Yang YY, Fan W, Wu M. A novel chemosynthetic peptide with β-sheet motif efficiently kills Klebsiella pneumoniae in a mouse model. Intl J Nanomedicine. 10:1045-1059, 2015 (IF 4.38)

　　39. Jiang DH, Huang H,Han N, Xu M, Xu L,Zhou L, Wang S. and Fan W*. Fulvestrant, a Selective Estrogen Receptor Down-regulator, Sensitizes Estrogen Receptor Negative Breast Tumors to Chemotherapy. Cancer Letters, 346:292-299, 2014 (IF 5.61)

　　40. Fan W*, Chang JJ and Fu PF. Endocrine Therapy Resistance in Breast Cancer: Current Status, Possible Mechanisms and Overcoming Strategies. Future Medicinal Chem, 7:1511-1519, 2015 (IF 3.74)

　　41. Xu L, lei JY, Jiang DH, Zhou L, Wang S and Fan W*. Reversal effects of raloxifene on paclitaxel resistance in two MDR breast cancer cells. Cancer Biology Thearpy. In Press, 2015 (IF 3.01)

　　42. Cheng JC, Chin W, Dong WW, Xu L, Zhong GS, Huang Y, Li LJ, Xu K, Wu M, Hedrick JL, Yang YY and Fan W*. Biodegradable Antimicrobial Polycarbonates with In Vivo Efficacy against Multidrug-Resistant MRSA Systemic Infection. Adv. Healthcare Materials. [Epub Ahead of Print] 2015 (IF 5.80)

　　BOOK CHAPTERS

　　1. Fan W. and Sui M. Glucocorticoids Mediate Drug Resistance: Mechanisms and Its Clinical Impact. In Book “Glucocorticoids: Effects, Action. Mechanism, and Therapeutic Uses”. pp147-167，Pelt, A.C.(eds),Nova Science Publishers, 2010

　　2. Fan W.and Sui M: Roles and Mechanisms of Estrogen and Estrogen Receptors in Breast Cancer Resistant to Chemotherapy. In Book “Breast Cancer: Current and Alternative Therapeutic Modalities" Cells”Gunduz E (eds). InTech Publishers, 2011 (*This book charpter has been downloaded more than 2000 times by the readers over 100 countries)

　　3. Chang, JJ and Weimin Fan*, Endocrine Therapy Resistance In Breast Cancer: Current Status, Possible Mechanisms and Overcoming Strategies. In Book "Medicinal chemistry advances: overcoming multidrug resistance in oncology". Ryan De Vooght-Johnson (eds). In Press, Future Science Ltd, UK. 2014

　　技术专利：

　　1. 源于BCap37的乳腺癌耐药细胞株及其应用。范伟民，蒋东海，隋梅花。专利申请号：201010502654.6;发明专利证书号：CN 1149981

　　2. 氟维司群在制备抗微管类化疗药物耐药逆转剂中的应用。范伟民，蒋东海，隋梅花。专利申请号：201110047575.5;公开(公告)号：CN102151277A

　　研究课题：

　　1. 多功能纳米颗粒技术与新型抗癌药物的研究和开发(浙江省科技厅国际重大专项)10/2008-09/2011

　　2. 新型靶向性纳米生物化疗药物治疗HER2+乳腺癌的体内外研究(国家自然科学基金)01/2010-12/2012

　　3. 杭州抗体与靶向治疗研发技术平台(杭州市新药港建设委员会)8/2010-7/2012

　　4. 雌激素受体介导乳腺癌对紫杉醇耐药及其逆转途径的体内研究(国家自然科学基金)01/2011-12/2013

　　5. MSC-L的抗肿瘤基质细胞作用及其抑癌功效的研究(国家自然科学基金)01/2014-12/2017

　　6. 新型抗菌药物β-折叠抗菌肽的临床前研究 (国家科技重大专项:重大新药创制)05/2014-04/2017

　　7. miRMA-20-20a-5p家族调控家族乳腺癌耐受紫杉醇的作用机制研究及其临床意义(国家自然科学基金)01/2016-12/2019