武汉大学医学研究院博士生导师简介：章晓联

　　学术兼职

　　中华医学会微生物及免疫学会副主任委员

　　中国医学装备协会现场快速检测(POCT)装备技术专业委员会常务委员

　　中国免疫学会理事

　　武汉市免疫学会副理事长

　　中国生物化学与分子生物学学会糖复合物专业委员会委员

　　武汉大学医学部学术委员

　　“Frontiers in Cellular and Infection Microbiology”杂志的review editor 编委; “Infectious Disorders - Drug Targets'” Editorial Board Members;

　　“Open Glycoscience” Editorial Board Members;

　　《中国病毒学》编委

　　《中国生化药物杂志》编委

　　《武汉大学学报》英文版杂志编委

　　目前研究资助

　　国家重大传染病专项、国家基金委项目和湖北省医学领军人才项目等。

　　发表论文概况

　　研究成果发表论文122篇，SCI论文84篇，被Nature等国际权威杂志SCI他引用1000余次。论文多次曾被FACULTY of 1000引用，评价为Top2%;申请发明专利40项，获得授权发明专利28项。获中华医学奖二等奖、湖北省自然科学一等、二等奖等。国际会议大会邀请报告10余次。

　　代表性论文

　　1. Luo W, Qu Z, Xie Yan, Xiang J, Zhang XL*. (2015) Identification of a novel immunodominant antigen Rv2645 from RD13 with potential as a cell-mediated immunity-based TB diagnostic agent. J Infect. 2015. 71 (5)：534-543.

　　2. Ren Y, Min Y-Q, Liu M, Chi Lianli, Zhao P, Zhang XL*. (2015) N-glycosylation-mutated HCV envelope glycoprotein complex enhances antigen-presenting activity and cellular and neutralizing antibody responses. Biochim.Biophys. Acta 2015, http://dx.doi.org/10.1016/j.bbagen.2015.08.007

　　3. Pan Q, Li Q, Liu S, Ning N, Zhang X, Xu Y, Chang AE, Wicha MS. (2015) Targeting Cancer Stem Cells Using Immunologic Approaches. Stem Cells. 33(7):2085-92.

　　4. Wang T, Hong T, Huang Y, Su H, Wu F, Chen Y, Wei L, Huang W, Hua X, Xia Y, Xu J, Gan J, Yuan B, Feng Y, Zhang X, Yang CG, Zhou X. (2015) Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein. J Am Chem Soc. 137(43):13736-9.

　　5. Ding F, Guo S, Xie M, Luo W, Yuan C, Huang W, Zhou Y, Zhang XL*, Zhou X*. (2015) Diagnostic applicants of gastric carcinomacell aptamers in vitro and in vivo. Talanta. 134:30-36.

　　6. Chen T, Hu Y, Ding Q, Yu J, Wang F, Luo F*, Zhang XL*. (2015) Serum ficolin-2 concentrations are significantly changed in patients with hepatitis B virus infection and liver diseases. Virol Sin. 30 (4): 249-260.

　　7. Zhao Y, Ren Y, Zhang X, Zhao P, Tao W, Zhong J, Li Q, Zhang XL*. (2014). Ficolin-2 inhibits Hepatitis C Virus infection, whereas apolipoprotein E3 mediates viral immune escape. J Immunol. 193(2):783-96 , cited by F1000Prime

　　8. Pan Q, Wang Q, Sun X, Xia X, Wu S, Luo F, Zhang XL*. (2014). Aptamer against mannose-capped lipoarabinomannan inhibits virulent Mycobacterium tuberculosis infection in mice and rhesus monkeys. Mol Ther. 22(5):940-51.

　　9. Tang XL, Zhou YX, Wu SM, Pan Q, Xia B, Zhang XL*. CFP10 and ESAT6 aptamers as effective Mycobacterial antigen diagnostic reagents. J Infect. 2014 , 69: 569-580.

　　10. Wu SM, Ai HW, Zhang DY, Han XQ, Pan Q, Luo FL, Zhang XL*. (2014) miR-141 targets ZEB2 to suppress HCC progression. Tumour Biol. 35(10):9993-7.

　　11. Ding F, Yuan C, Wu F, Peng S, Tian S, Zhang XL*, Zhou X*.(2014) Diagnosis applicants of new hepatoma carcinoma cell aptamers in vitro. Anal. Methods. 6: 8110-8114

　　12. Luo F, Sun X, Wang Y, Wang Q, Wu Y, Pan Q, Fang C, Zhang XL*. (2013). Ficolin-2 defends against virulent Mycobacteria Tuberculosis infection in vivo, and its insufficiency is associated with infection in humans. PloS One, 8 (9): e73859.

　　13. Hu Y, Luo F, Fu J, Chen T, Wu S, Zhou Y, Zhang XL*. (2013) Early increased ficolin-2 concentrations are associated with severity of liver inflammation and efficacy of anti-viral therapy in chronic hepatitis C patients. Scand J Immunol 77:144-150.

　　14. Yilan Hu, Fengling Luo, Junliang Fu, Tielong Chen, Shimin Wu, Yi-Dan Zhou, Xiao-Lian Zhang*. (2013) Early increased ficolin-2 concentrations are associated with severity of liver inflammation and efficacy of anti-viral therapy in chronic hepatitis C patients. Scand J Immunol. 77:144-150.