浙江大学医学院博士研究生导师简介：王建安

　　31、钾离子通道蛋白Kv2.1对骨髓间充质干细胞迁移的作用及机理研究 教育部博士点基金

　　32、 胚胎干细胞移植修复衰竭心脏的实验研究 浙江省自然科学基金

　　33、新型国产动脉带膜支架与实时压力监测系统的开发 浙江省科技计划重点项目

　　34、创建区域医疗和分级诊疗模式的研究 浙江省医院可持续发展扬子江研究基金

　　35、 自体骨髓间质干细胞移植修复衰竭心脏 浙江省医药卫生优秀青年人才专项科研基金

　　36、通心络对高脂血症家兔血浆不对称二甲基精氨酸的影响 浙江省中医局

　　37、自体骨髓干细胞间充质细胞移植治疗急性心肌梗死的临床研究 浙江省卫生厅一般项目

　　38、自体骨髓间质干细胞移植修复 浙江省卫生厅一般项目

　　39、构建省、县、乡一体化联合诊断模型 浙江省卫生厅农村卫生管理处

　　40、医院国际人力资源管理的应用 浙江省医院管理学会康恩贝41、通心络促进血管新生的机制研究 浙江省中医名科项目建设项目

　　三、获奖情况和重要荣誉

　　1、2000年 《二尖瓣口短暂球囊充盈对左心耳云雾影和流速的影响》

　　浙江省自然科学优秀论文奖一等奖

　　2、2001年 《二尖瓣口短暂球囊充盈对左心耳云雾影和流速的影响》 浙江省科技进步奖二等奖

　　3、2001年《心脏瓣膜病学》 浙江省高校科研成果奖二等奖

　　4、2002年《二尖瓣狭窄左心房血栓前状态局部凝血功能异常的研究》 浙江省科学技术奖三等奖

　　5、2004年《心房颤动经导管消融治疗的研究》 中华医学科技奖三等奖(参与)

　　6、2005年《二尖瓣狭窄左心房局部凝血功能异常的研究及临床应用》

　　浙江省科技进步奖二等奖、浙江省高校科研成果奖一等奖

　　7、2008年《干细胞治疗心功能不全的基础和临床研究》 浙江省科技进步奖一等奖

　　8. 2010年，2009-2010年度卫生部有突出贡献中青年专家

　　9、2011年，浙江省有突出贡献中青年专家

　　10.、2012年，最具领导力中国医院院长

　　11.2012年度中国十大医改新闻人物

　　四、专利情况

　　已授权专利：

　　1. 2010年，ZL200810121846.5，一种增强人骨髓间充质干细胞旁分泌能力的处理方法，排名1/5

　　2. 2011年，ZL200910097997.6，一种增强骨髓间充质干细胞抗细胞凋亡能力的处理方法，排名1/3

　　3. 2011年，ZL200910099469.4，一种骨髓间充质干细胞体外培养基及其应用，排名1/2

　　4. 2011年，ZL201010256948.5，红曲在制备防治腹主动脉瘤药物中的应用，排名2/3

　　已受理专利：

　　1. 201010557496.4 一种提高间充质干细胞迁移能力的预处理方法，排名第一

　　五、主要论文

　　英文文章

　　1.Liu XB, Chen H, Chen HQ, Zhu MF, Hu XY, Wang YP, Jiang Z, Xu YC, Xiang MX, Wang JA. Angiopoietin-1 preconditioning enhances survival and functional recovery of mesenchymal stem cell transplantation.J Zhejiang Univ Sci B. 2012 Aug;13(8):616-23.

　　2.Jiang J, Sun Y, Xiang MX, Dong L, Liu XB, Hu XY, Feng Y, Wang JA. Complex coronary lesions and rotational atherectomy: one hospital's experience. J Zhejiang Univ Sci B. 2012 Aug;13(8):645-51.

　　3.Shen L, Song LG, Ma H, Jin CN, Wang JA, Xiang MX. Tea consumption and risk of stroke: a dose-response meta-analysis of prospective studies. J Zhejiang Univ Sci B. 2012 Aug;13(8):652-62.

　　4.Jiang Z, Chen H, Wang J.Right coronary artery fistula to left ventricle treated by transcatheter coil embolization: a case report and literature review. Intern Med. 2012;51(11):1351-3.

　　5.Qiyuan Xu, Jian An Wang, Jinlin He, Mingsheng Zhou, Jennipher Adi, Keith A. Webster,Hong Yu. Impaired CXCR4 expression and cell engraftment of bone marrow-derived cellsfrom aged atherogenic mice. Atherosclerosis. 219 (2011): 92–99.

　　6. Hongwei Shao , Qiyuan Xu , Qiuling Wu, Qi Ma , Luis Salgueiro,Jian’An Wang, Darwin Eton, Keith A. Webster, Hong Yu. Defective CXCR4 expression in aged bone impairs vascular regeneration. J. Cell. Mol. Med. 2011;15(10): 2046-2056.

　　7. Meixiang Xiang, Jiusong Sun, Yan Lin, Jie Zhang, Han Chen, Dan Yang, Jianan Wang, Guo-Ping Shi .Usefulness of serum tryptase level as an independent biomarker for coronary plaque instability in a Chinese population. Atherosclerosis.215 (2011) :494–499.

　　8. Yaping Wang, Xinyang Hu, Xiaojie Xie, Aina He, Xianbao Liu and Jian-an Wang. Effects of mesenchymal stem cells on matrix metalloproteinase synthesis in cardiac fibroblasts. Experimental Biology and Medicine. 236(2011):1197-1204.

　　9. Chun-na Jin , Hong Ma , Yan Lin , Jian-an Wang , Mei-xiang Xiang. Association between SNP rs1800875, Serum Chymase and immunoglobin E levels in patients with coronary heart diseasea. J Zhejiang Univ-Sci B (Biomed & Biotechnol) .2011; 12(8):660-667.

　　10.Guodong Jin, Beili Feng, Peng Chen, Oushan Tang, Jian Wang, Ji Ma, Yuping Shi, Geng Xu.Coagulation Factor XIII-A Val34Leu Polymorphism and the Risk of Coronary Artery Disease and Myocardial Infarction in a Chinese Han Population. Clin Appl Thromb Hemost. 2011 Apr;17(2):208-13.

　　11. Xiaojie Xie, Yifan Wang, Songzhao Zhang, Guidi Zhang, Yinchuan Xu, Honghao Bia,Alan Daughertyc, Jian-an Wang.Chinese red yeast rice attenuates the development of angiotensin II-induced abdominal aortic aneurysm and atherosclerosis. Journal of Nutritional Biochemistry(2011).

　　12. Wen-xia Wang, Xin-yang Hu, Xiao-jie Xie, Xian-bao Liu, Rong-rong Wu, Ya-ping Wang, Feng Gao, Jian-an Wang. Nerve growth factor induces cord formation of mesenchymal stem cell by promoting proliferation and activating the PI3K/Akt signaling pathway. Acta Pharmacologica Sinica .(2011) 32: 1483–1490.

　　13. Jian-an Wang, Wen-aiChen, YifanWang, SongzhaoZhang, HonghaoBi, BoHong, Yueqiu Luo, AlanDaugherty, XiaojieXie. Statins exert differential effects on angiotensin II-induced atherosclerosis, but no benefit for abdominal aortic aneurysms. Atherosclerosis

　　14. Hu X, Wei L, Taylor TM, Wei J, Zhou X, Wang JA, Yu SP. Hypoxic Preconditioning Enhances Bone Marrow Mesenchymal Stem Cell Migration via Kv2.1 Channel and FAK Activation. Am J Physiol Cell Physiol. 2011 May 11.

　　15. Yaping Wang, Xinyang Hu, Jian-an Wang, Meixiang Xiang , Jiekai Yu, Fangfei Liu, Yan Feng . Application of serum protein fingerprint in diagnosis of coronary artery disease. Clinical Biochemistry. 44 (2011) 185–191.

　　16. Wang JA. Advances in cardiovascular disease: how far is the summit? Journal of Zhejiang University Science-B. 2010 11(8):547.

　　17. Feng Gao, Xin-yang Hu, Xiao-jie Xie, Qi-yuan Xu, Ya-ping Wang, Xian-bao Liu, Mei-xiang Xiang, Yong Sun, Jian-an Wang . Heat shock protein 90 protects rat mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis via the PI3K/Akt and ERK1/2 pathways. Zhejiang Univ-Sci B (Biomed & Biotechnol).2010 11(8):608-617.

　　18. Xiao-hong Pan, Ying-xue Chen, Mei-xiang Xiang, Geng Xu, Jian-an Wang. A meta-analysis of randomized trials on clinical outcomes of paclitaxel-eluting stents versus bare-metal stents in ST-segment elevation myocardial infarction patients.Zhejiang Univ-Sci B (Biomed & Biotechnol) 2010;11(10):754-761.

　　19. Chang Bian, Geng Xu, JiananWang, JiMa, MeiXiang Xiang, and Peng Chen. Hypercholesterolaemic Serum Increases the Permeability of Endothelial Cells through Zonula Occludens-1 with Phosphatidylinositol 3-Kinase Signaling Pathway. Journal of Biomedicine and Biotechnology. 2010 Jan.

　　20. Shu-qin Ying, Mei-xiang Xiang, Lu Fang, Jian-an Wang. Temporal changes in circulating P-selectin, plasminogen activator inhibitor-1, magnesium, and creatine kinase after percutaneous coronary intervention. Zhejiang Univ-Sci B (Biomed & Biotechnol) 2010 11(8):575-582.

　　21. Chang Bian, Yihua Wu, Yu Shi, Geng Xu, Jianan Wang, Meixiang Xiang, Shaoxiang Weng, Jun Jiang and Ji Ma. Predictive value of the relative lymphocyte count in coronary heart disease. Heart Vessels. 2010 Nov;25(6):469-73.

　　22. Li-jiang Tang, Jian-jun Jiang, Xiao-feng Chen, Jian-an Wang, Xian-fang Lin, Yu-xi Du, Cong-feng Fang,Zhao-xia. Relation of uric acid levels to aortic root dilatation in hypertensive patients with and without metabolic syndrome. Zhejiang Univ-Sci B (Biomed & Biotechnol) 2010 11(8):592-598.

　　23. He A, Jiang Y, Gui C, Sun Y, Li J, Wang JA.The antiapoptotic effect of mesenchymal stem cell transplantation on ischemic myocardium is enhanced by anoxic preconditioning. Canadian Journal of Cardiology. 2009 Jun;25(6):353-8.

　　24. Wang JA, Chen XF, Yu WF, Chen H, Lin XF, Xiang MJ, Fang CF, Du YX, Wang B. Relationship of heavy drinking, lipoprotein (a) and lipid profile to infrarenal aortic diameter. Vascular Medicine. 2009 Nov;14(4):323-9.

　　25. Mei-xiang Xiang, Ai-na He, Jian-an Wang,and Chun Gui. Protective paracrine effect of mesenchymal stem cells on cardiomyocytes. Journal of Zhejiang University-Science B. 2009 August; 10(8): 619–624.

　　26. Chen XF, Wang JA, Hou J, Gui C, Tang LJ, Chen XQ, Xie XJ, Jiang JJ, Cai JF, Chen HS, Lu HS, Chen H. Extracellular matrix metalloproteinase inducer (EMMPRIN) is present in smooth muscle cells of human aneurysmal aorta and is induced by Angiotensin II in vitro. Clin Sci(Lond). 2009 May 1;116(11):819-27

　　27. Wang JA, He A, Hu X, Jiang Y, Sun Y, Jiang J, Gui C, Wang Y, Chen H. Anoxic preconditioning: A way to enhance the cardioprotection of mesenchymal stem cells. Int J Cardiol. 2008 Apr 17;133(3):410-2.

　　28. Liu XB, Wang JA, Ogle ME, Wei L. Prolyl hydroxylase inhibitor dimethyloxalylglycine enhances mesenchymal stem cell survival. J Cell Biochem. 2009 Feb 19.

　　29. Jiang J, Wang J, Li C, Yu SP, Wei L. Dual roles of tumor necrosis factor-{alpha} receptor-1 in a mouse model of hindlimb ischemia. Vasc Med. 2009 Feb;14(1):37-46.

　　30. Pan XH, Zhong WZ, Xiang MX, Xu G, Shan J, Wang JA. Clinical outcomes of serolimus-eluting stents versus bare metal stents in ST-segment elevation myocardial infarction patients: a meta-analysis.Chin Med J (Engl). 2009 Jan 5;122(1):88-92.