武汉大学药学院博士生导师简介：洪葵

　　在研项目：

　　2012.1- 2016.12 欧盟第七框架项目(FP7)，“Increasing Value and Flow in the Marine Biodiscovery Pipeline” in short PharmaSea (Project ID 312184)

　　2012.1-2016.12 “973”子课题 “红树林微生物药物合成专用功能元件挖掘”

　　近年发表的代表性论文:

　　1. Chai H, Yin R, Liu Y, Meng H, Zhou X, Zhou G, Bi X, Yang X, Zhu T, Zhu W, Deng Z, Hong K*. Sesterterpene ophiobolin biosynthesis involving multiple gene clusters in Aspergillus ustus. Sci Rep. 2016 Jun 7; 6:27181. doi: 10.1038/srep27181.

　　2. Zhang L, Ruan C, Peng F, Deng Z, Hong K*. Streptomyces arcticus sp. nov., isolated from the Arctic. Int J Syst Evol Microbiol. 2016 Jan 19. doi: 10.1099/ijsem.0.000907. [Epub ahead of print]

　　3. Xie QY, Ren J, Li L, Li Y, Deng ZX, Hong K*. Micromonospora mangrovi sp. nov., isolated from mangrove soil. Antonie Van Leeuwenhoek. 2016 Apr;109(4):483-91. doi: 10.1007/s10482-015-0641-x. Epub 2016 Mar 4

　　4. Mostafa E. Rateb, Yin Zhai, Emmanuelle Ehrner, Christopher M. Rath, Xiaoling Wang, Jioji Tabudravu, Rainer Ebel, Mervin Bibb, Kwaku Kyeremeh, Pieter C. Dorrestein, Kui Hong,* Marcel Jaspars*, Hai Deng*.Legonaridin, a new member of linaridin RiPP from a Ghanaian Streptomyces isolate. Organic & Biomolecular Chemistry, 2015. DOI: 10.1039/c5ob01269d

　　5. Xu D, Ma M, Liu Y, Zhou T, Wang K, Deng Z, Hong K*. PreQ0 base, an unusualmetabolite with anti-cancer activity from Streptomyces qinglanensis 172205. Anticancer Agents Med Chem. 2015;15(3):285-90.

　　6. Xu DB, Ma M, Deng ZX, Hong K*. Genotype-driven isolation of enterocin with novel bioactivities from mangrove-derived Streptomyces qinglanensis 172205. Appl Microbiol Biotechnol. 2015 Jul; 99(14):5825-32. doi: 10.1007/s00253-015-6574-5. Epub 2015 Apr 17

　　7. Yin Zhai, Bin Cheng, Juan Hu, Kwaku Kyeremeh, Xiaoling Wang, Marcel Jaspars, Hai Deng, Zi-Xin Deng, Kui Hong*, Draft genome sequence of Streptomyces sp. strain CT34, isolated from a Ghanaian soil sample, Genome announcements, 2015 Feb 5;3(1). pii: e01508-14. doi: 10.1128/genomeA.01508-14

　　8. Lv C, Qin W, Zhu T, Wei S, Hong K*, Zhu W, Chen R, Huang C. Ophiobolin O isolated from Aspergillus ustus induces G1 arrest of MCF-7 cells through interaction with AKT/GSK3β/cyclin D1 signaling. Mar Drugs. 2015 Jan 16;13(1):431-43. doi: 10.3390/md13010431.

　　9. Xu DB, Ye WW, Han Y, Deng ZX, Hong K*. Natural Products from Ma, ngrove Actinomycetes. Marine Drugs. 2014, 12, 2590-2613; doi:10.3390/md12052590

　　10. Sun W, Lv C, Zhu T, Yang X, Wei S, Sun J, Hong K*, Zhu W*, Huang C*. Ophiobolin-O Reverses Adriamycin Resistance via Cell Cycle Arrest and Apoptosis Sensitization in Adriamycin-Resistant Human Breast Carcinoma (MCF-7/ADR) Cells. Marine Drugs. 2013; 11:4570-4584.

　　11. Yuan GJ, Hong K*, Lin HP, She ZG, Li J. New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells. Marine Drugs. 2013, 11, 817-829

　　12. Li T , Du YY , Cui Q , Zhang JT, Zhu W, Hong K*, Li WL*. Cloning, Characterization and Heterologous Expression of the Indolocarbazole Biosynthetic Gene Cluster from Marine-Derived Streptomyces sanyensis FMA, Marine Drugs. 2013，11, 466-488,

　　13. Fu P, Yang Cl, Wang Y, Liu PP, Ma YM, Xu L, Su MB, Hong K,* and Zhu WM *. Streptocarbazoles A and B, Two Novel 2 Indolocarbazoles from the Marine-Derived Actinomycete Strain Streptomyces sp. FMA. Organic Letters. 2012，14 (9): 2422–2425

　　14. Yang TT, Lu ZY, Meng L, Wei SJ, Hong K*, Zhu WM *, Huang CG *. The Novel Agent Ophiobolin O Induces Apoptosis and Cell Cycle Arrest of MCF-7 Cells Through Activation of MAPK Signaling Pathways. Bioorganic & Medicinal Chemistry Letters. 2012. 22:579–585

　　15. Hu H, Lin HP, Xie QY, Li L, Xie XQ, Hong K*. Streptomyces qinglanensis sp. nov., Isolated from Mangrove Sediment. International Journal of Systematic and Evolutionary Microbiology. 2012，62: 596–600.

　　16. Xie QY, Hong K*, Goodfelllow M. Genus-specific Primers Targeting the 16S rRNA Gene for PCR Detection of Members of the Genus Verrucosispora. Antonie van Leeuwenhoek. 2011, 100:117-128;

　　17. Xie QY, Wang C, Wang R, Qu Z, Lin HP, Goodfellow M, and Hong K*，Jishengella endophytica gen. nov., sp. nov., a New Member of the Family Micromonosporaceae，International Journal of Systematic and Evolutionary Microbiology. 2011, 61, 1153–1159.

　　18. Chen GD, Gao H, Tang JS, Huang YF, Chen Y, Wang Y, Zhao HN, Lin HP, Xie QY, Hong K, Li J, Yao XS*. Benzamides and Quinazolines from a Mangrove Actinomycetes Streptomyces sp. (No. 061316) and Their Inhibiting Caspase-3 Catalytic Activity in vitro. Chemistry Pharmacy Bullitin. 2011, 59: 447—451.

　　19. Wang C, Xu XX, Qu Z, Wang HL, Lin HP, Xie QY, Ruan JS and Hong K *，Micromonospora rhizosphaerae sp. nov., Isolated from Mangrove Rhizosphere Soil. International Journal of Systematic and Evolutionary Microbiology. 2011 61, 320–324.

　　20. Yuan GJ, Lin HP, Wang C, Hong K*, Liu Y, Li J. The 1H and 13C Resonance of Two New Macrocyclic Lactones Isolated from Streptomyces sp. 211726 and Revised Assignments of Azalomycins F3a, F4a and F5a. Magnetic resonance in chemistry. 2011, 49, 30–37.

　　21. Lu ZY, Wang Y, Miao CD, Liu PP, Hong K,*and Zhu WM *, Sesquiterpenoids and Benzofuranoids from the Marine-Derived Fungus Aspergillus ustus 094102，J. Nat. Prod. 2009, 72, 1761–1767

　　22. Hong K*, Gao AH, Xie QY, Gao H, Zhuang L, Lin HP, Yu HP, Li J, Yao XS, Goodfellow M, and Ruan JS. Actinomycetes for Marine Drug Discovery Isolated from Mangrove Soils and Plants in China. Marine Drugs 2009, 7: 24-44

　　申请及授权专利：

　　1. 洪葵， 孟会影，柴沆镇，殷如，邓子新。一种蛇孢假壳素类化合物母核合成基因AuOS及其应用。申请号：201510130163.6， 申请日期：2015.3.24

　　2. 洪葵，韩莹，田二丽，马敏，邓子新。一株高产洋橄榄叶素类化合物的菌株及该类化合物的制备方法与应用。申请号：201510260295.0，申请日期：2015.5. 20

　　3. 洪葵， 叶弯弯，邓子新。一种具有抑制Aβ聚集活性的化合物的制备方法与用途。申请号：201501151251.4， 申请日期： 2015. 4. 01。

　　4. 洪葵，徐东波，马敏，邓子新。一种具有抑制Aβ聚集活性的化合物的制备方法与用途。申请号：201410499832.2， 申请日期：2014.9.25

　　5. 洪葵、潘洁. 一种高产阿扎霉素F类化合物菌株链霉菌TKPJ3039及其应用，ZL201310199811.4 授权日期2014.11.4

　　6. 洪葵、杨雪. 一种高产蛇孢假壳类化合物菌株焦曲霉TKYX429及其应用，ZL201310186483.4授权日期2014.08.13

　　热忱欢迎有共同兴趣的硕、博研究生或博士后加盟，一起发现海洋微生物新药!