北京大学分子医学研究所博士生导师简介：肖瑞平

　　19. Chakir, K., Xiang, Y., Zhang, S.J., Yang, D., Cheng, H., Kobilka, B.K., and Xiao, R.P.: The third intracellular loop and the carboxyl terminus of beta2-adrenergic receptor confer the receptor spontaneous activity. Mol. Pharmacol. 64: 1048-1058, 2003.

　　18. Xiao, R.P., Zhang, S.J. Kuschel, M., Zhou, Y.Y., Bond, R.A., Balke, C.W., Lakatta, E.G., and Cheng, H.: Enhanced Gi signaling mediates the diminution of beta2-adrenergic contractile response in failing spontaneous hypertensive rat heart. Circulation. 108:1633-1639, 2003.

　　17. Song, L.S., Guia, A., Muth, J.N., Wang, S.Q., Xiao, R.P., Josephson, I.R., Schwartz, A., Lakatta, E.G., and Cheng, H.: Ca2+ signaling in hypertrophic transgenic cardiac myocytes overexpressing the α1 subunit of L-type Ca2+ channel. Circ. Res. 90: 174-181, 2002.

　　16. Liao, P., Wang, S.Q., Zheng, M., Zheng, M.Z., Cheng, H., Wang, Y., and Xiao, R.P.: p38 mitogen activated protein kinase mediates negative inotropic effect in cardiac myocytes. Circ. Res. 90: 190-196, 2002.

　　15. Hagemann, D., and Xiao, R.P.: Dual site phospholamban phosphorylation and its physiological relevance in the heart. Trends Cardiovasc Med. 12: 51-56, 2002 (Invited review).

　　58. Jo, S.H., Leblais, V., Crow, M.T., and Xiao, R.P.: Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent Gs signaling during beta2-adrenergic stimulation. Circ. Res. 91: 46-53, 2002.

　　14. Lavoie, C., Mercier, J.F., Salahpour, A., Umapathy, D., Breit, A., Villeneuve, L.R., Zhu, W.Z., Xiao, R.P., Lakatta, E.G., Bouvier, M., and Hébert, T.E.: beta1/beta2-adrenergic receptor heterodimerization regulates beta2-adrenergic receptor internalization and ERK signaling efficacy. J. Biol. Chem. 277: 35402-35410, 2002.

　　13. Zhu, W.Z., Zheng, M., Lefkowitz, R.J., Koch, W.J., Kobilka, B., and Xiao, R.P.: Dual modulation of cardiac cell survival and cell death by beta2-adrenergic signaling in adult mouse heart cells. Proc. Nat. Acad., Sci. USA 98: 1607-1612, 2001.

　　12. Song, L.S., Wang, S.Q., Xiao, R.P., Spurgeon, H., Lakatta, E.G., and Cheng, H.: beta-adrenergic stimulation synchronizes intracellular Ca2+ release during excitation-contraction coupling in cardiac myocytes. Circ. Res. 88: 794-801, 2001.

　　11. Liao, P., Georgakopoulos, D., Kovacs, A., Zheng, M., Lerner, D., Pu, H., Saffitz, J., Chien, K., Xiao, R.P., Kass, D.A. and Wang, Y.: The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. Proc. Nat. Acad., Sci. USA 98: 12283-12288, 2001.

　　10. Xiao, R.P.: β-adrenergic signaling in the heart: Dual coupling of the β2-adrenergic receptor to Gs and Gi proteins. Science's STKE. 16: RE15, 2001 (Invited review).

　　9. Zhang, S.J., Cheng, H., Zhou Y.Y., Wang, D.J., Zhu, W., Ziman, B., Spurgeon, H., Lefkowitz, R.J., Lakatta, E.G., Koch, W.J., and Xiao, R.P.: Inhibition of spontaneous beta2-adrenergic activation rescues beta1-adrenergic contractile response in cardiomyocytes overexpressing beta2-adrenoceptor. J. Biol. Chem. 275: 21773-21779, 2000.

　　8. Hagemann, D., Kuschel, M., Kuromochi, T., Zhu, W., Cheng, H., and Xiao, R.P.: Frequency-encoding Thr17 phospholamban phosphorylation is independent of Ser16 phosphorylation in cardiac myocytes. J. Biol. Chem. 275: 22532-22536, 2000.

　　7. Zhou, Y.Y., Wang, S.Q., Zhu, W., Chruscinski, A., Kobilka, B., Ziman, B., Wang, S., Lakatta, E.G., Cheng, H., and Xiao, R.P.: High efficient adenovirus-directed gene transfer in cultured adult mouse ventricular myocytes. Am. J. Physiol. 279: H429-H436, 2000.

　　6. Vinogradova, T.M., Zhou, Y.Y., Bogdanov, K.Y., Kuschel, M., Cheng, H., and Xiao, R.P.: Sinoatrial node pacemaker activity requires Ca2+/calmodulin-dependent protein kinase II activation. Circ. Res. 87: 760-767, 2000.

　　5. Xiao, R.P.: Cell logic for dual coupling of a single class of receptors to Gs and Gi proteins. Cric. Res. 87: 635-637, 2000 (Editorial).

　　4. Zhou, Y.Y., Zhu, W., Zhang, S..J., Wang, D.J., Kobilka, B., Lakatta, E.G., Cheng, H., and Xiao, R.P.: Ligand-independent activation of beta2- but not b1-adrenoceptor overexpressed in beta1/beta2-adrenoceptor double knockout mouse cardiomyocytes. Mol. Pharmacol. 58: 887-894, 2000.

　　3. Chen, Y., Xiao*, R.P. Izu, L.T., Cheng, H., Kuschel, M., Spurgeon, H., and Lakatta, E.G.: Gi-dependent localization of beta2-adrenergic receptro signaling to L-type Ca2+ channels. Biophys. J. 79: 2547-2556, 2000 (* The corresponding author).

　　2. Chesley, A., Ohtani, S., Asai, T., Xiao, R.P., Lunberg, M.S., Lakatta, E.G., and Crow M.T.: beta2-adrenergic receptor delivers an anti-apoptotic signal to cardiac myocytes through Gi-dependent signaling pathways. Circ. Res. 87: 1172-1179, 2000.

　　1. Zheng, M., Zhang, S.J., Zhu, W., Ziman, B., Kobilka, B.K., and Xiao, R.P.: beta2-adrenergic receptor-induced p38 MAPK activation is mediated by PKA rather than by Gi or Gb in adult mouse cardiomyocytes. J. Biol. Chem. 275: 40635-40640, 2000.