武汉大学第一临床学院博士生导师简介：刘修恒

　　6.LSD1介导前列腺癌侵袭转移的作用机理研究，2012FFA096，省自然科学基金，10万，2013.1-2014.12，未完成，主持

　　7.湖北省首届领军人才培养工程培养对象，湖北省卫生与计划生育委员会，60万，2013-2015.

　　8.关键抑癌基因RKIP在前列腺癌侵袭转移中作用及机制研究，JX6B62，省卫生厅一般项目，1万，2013.1-2014.12,主持

　　9.特异性RNA干扰树突状细胞RelB诱导同种移植免疫耐受，编号无，武汉大学医学部协同创新项目，8万，2014.1-2016.12，主持

　　10.抑癌miRNA串联体表达系统逆转前列腺癌恶性表型的实验研究，2015060101010049，武汉市应用基础研究计划项目，15万，2015-2016.主持

　　成果获奖：

　　1.输精管过滤装置可复性节育术的实验研究 获省科技进步三等奖 1991.3

　　2.前列腺癌组织中HNK-1抗原的分布及其对预后判断的意义 获省科技进步三等奖 2001. 8

　　3.镰刀状肾实质切开术治疗复杂性肾结石 获省科技进步二等奖 2004

　　部分论文代表作：

　　1: Wang M, Weng X, Guo J, Chen Z, Jiang G, Liu X. Metformin alleviated EMT and fibrosis after renal ischemia-reperfusion injury in rats. Ren Fail. 2016 May;38(4):614-21. doi: 10.3109/0886022X.2016.1149770. Epub 2016 Feb 26. PubMed PMID: 26915376.

　　2: Chen Z, Liu X, Yu G, Chen H, Wang L, Wang Z, Qiu T, Weng X. Ozone therapy ameliorates tubulointerstitial inflammation by regulating TLR4 in adenine-induced CKD rats. Ren Fail. 2016 Feb 24:1-9. [Epub ahead of print] PubMed PMID: 26907800.

　　3: Wang M, Liu X, Guo J, Weng X, Jiang G, Wang Z, He L. Inhibition of LSD1 by Pargyline inhibited process of EMT and delayed progression of prostate cancer in vivo. Biochem Biophys Res Commun. 2015 Nov 13;467(2):310-5. doi: 10.1016/j.bbrc.2015.09.164. Epub 2015 Oct 3. PubMed PMID: 26435505.

　　4: Guo J, Wang M, Liu X. MicroRNA-195 suppresses tumor cell proliferation and metastasis by directly targeting BCOX1 in prostate carcinoma. J Exp Clin Cancer Res. 2015 Sep 4;34:91. doi: 10.1186/s13046-015-0209-7. PubMed PMID: 26338045;PubMed Central PMCID: PMC4559360.

　　5: Guo J, Liu X, Wang M. miR-503 suppresses tumor cell proliferation and metastasis by directly targeting RNF31 in prostate cancer. Biochem Biophys Res Commun. 2015 Sep 4;464(4):1302-8. doi: 10.1016/j.bbrc.2015.07.127. Epub 2015 Jul 29. PubMed PMID: 26231797.

　　6: Jiang G, Liu X, Wang M, Chen H, Chen Z, Qiu T. Oxymatrine ameliorates renal ischemia-reperfusion injury from oxidative stress through Nrf2/HO-1 pathway. Acta Cir Bras. 2015 Jun;30(6):422-9. doi: 10.1590/S0102-865020150060000008. PubMed PMID: 26108031.

　　7: Weng X, Wang M, Chen H, Chen Z, Liu X. Ischemic postconditioning inhibits apoptosis of renal cells following reperfusion: a novel in vitro model. Int Urol Nephrol. 2015 Jul;47(7):1067-74. doi: 10.1007/s11255-015-0997-x. Epub 2015 May 5. PubMed PMID: 25940033.

　　8: Jiang G, Wang M, Wang L, Chen H, Chen Z, Guo J, Weng X, Liu X. The protective effect of nesfatin-1 against renal ischemia-reperfusion injury in rats. Ren Fail. 2015 Jun;37(5):882-9. doi: 10.3109/0886022X.2015.1015426. Epub 2015 Feb 24. PubMed PMID: 25707521.

　　9: Wang L, Liu X, Chen H, Chen Z, Weng X, Qiu T, Liu L. Effect of picroside II on apoptosis induced by renal ischemia/reperfusion injury in rats. Exp Ther Med. 2015 Mar;9(3):817-822. Epub 2015 Jan 20. PubMed PMID: 25667634; PubMed Central PMCID: PMC4316970.

　　10: Wang M, Liu X, Jiang G, Chen H, Guo J, Weng X. Relationship between LSD1 expression and E-cadherin expression in prostate cancer. Int Urol Nephrol. 2015 Mar;47(3):485-90. doi: 10.1007/s11255-015-0915-2. Epub 2015 Jan 28. PubMed PMID: 25627913.

　　11.Chen, H., Xing, B., Wang, L., Weng, X., Chen, Z., and Liu, X. Aged kidneys are refractory to ischemic postconditioning in a rat model. Ren Fail, 36: 1575-1580, 2014.

　　12.Wang, H., Chen, H., Wang, L., Liu, L., Wang, M., and Liu, X. Acute hyperglycemia prevents dexmedetomidine-induced preconditioning against renal ischemia-reperfusion injury. Acta Cir Bras, 29: 812-818, 2014.

　　13.Wang, L., Chen, H., Liu, X. H., Chen, Z. Y., Weng, X. D., Qiu, T., and Liu, L. The protective effect of ozone oxidative preconditioning against hypoxia/reoxygenation injury in rat kidney cells. Ren Fail, 36: 1449-1454, 2014.

　　14.Wang, L., Chen, H., Liu, X. H., Chen, Z. Y., Weng, X. D., Qiu, T., Liu, L., and Zhu, H. C. Ozone oxidative preconditioning inhibits renal fibrosis induced by ischemia and reperfusion injury in rats. Exp Ther Med, 8: 1764-1768, 2014.

　　15.Youlin, K., Li, Z., Xin, G., Mingchao, X., Xiuheng, L., and Xiaodong, W. Enhanced function of cytotoxic T lymphocytes induced by dendritic cells modified with truncated PSMA and 4-1BBL. Hum Vaccin Immunother, 9: 766-772, 2013.

　　16.Youlin, K., Jianwei, Z., Xin, G., Li, Z., Xiaodong, W., Xiuheng, L., Hengchen, Z., and Zhiyuan, C. 4-1BB protects dendritic cells from prostate cancer-induced apoptosis. Pathol Oncol Res, 19: 177-181, 2013.

　　17.Hu, J., He, J., Kuang, Y., Wang, Z., Sun, Z., Zhu, H., and Liu, X. Expression and significance of 90K/Mac-2BP in prostate cancer. Exp Ther Med, 5: 181-184, 2013.

　　18.Qiu, T., Wang, L., Liu, X. H., Weng, X. D., Kuang, Y. L., Chen, Z. Y., Chen, H., and Zhu, H. C. Over-expressing transporters associated with antigen processing increases antitumor immunity response in prostate cancer. Cell Immunol, 279: 167-173, 2012.

　　19.Qiu, T., Zhou, J., Liu, X., Ge, M., and Chen, Z. The second short-term warm ischemia after vascular anastomosis did not affect early renal function recovery in renal transplantation: a case report. Front Med, 6: 329-331, 2012.

　　20.Weng, X., Shen, H., Kuang, Y., Liu, X., Chen, Z., Zhu, H., Jiang, B., Zhu, G., and Chen, H. Ischemic postconditioning inhibits the renal fibrosis induced by ischemia-reperfusion injury in rats. Urology, 80: 481-484, 2012.

　　21.Kuang, Y., Weng, X., Liu, X., Zhu, H., Chen, Z., and Chen, H. Effects of 4-1BB signaling on the biological function of murine dendritic cells. Oncol Lett, 3: 477-481, 2012.

　　22.Youlin, K., Li, Z., Xiaodong, W., Xiuheng, L., and Hengchen, Z. Combination immunotherapy with 4-1BBL and CTLA-4 blockade for the treatment of prostate cancer. Clin Dev Immunol, 2012: 439235, 2012.

　　23.Weng, X., Kuang, Y., Liu, X., Chen, Z., Zhu, H., Chen, H., Jiang, B., and Shen, H. Construction of a recombinant adenovirus co-expressing truncated human prostate-specific membrane antigen and mouse 4-1BBL genes and its effect on dendritic cells. Braz J Med Biol Res, 44: 186-192, 2011.

　　24.Jiang, B., Liu, X., Chen, H., Liu, D., Kuang, Y., Xing, B., and Chen, Z. Ischemic postconditioning attenuates renal ischemic/reperfusion injury in mongrel dogs. Urology, 76: 1511-1519, 2010.

　　25.Kuang, Y., Weng, X., Liu, X., Zhu, H., Chen, Z., Jiang, B., and Chen, H. Anti-tumor immune response induced by dendritic cells transduced with truncated PSMA IRES 4-1BBL recombinant adenoviruses. Cancer Lett, 293: 254-262, 2010.

　　26.Youlin, K., Xiaodong, W., Xiuheng, L., Zhiyuan, C., Hengcheng, Z., Hui, C., and Botao, J. The change of immunoactivity of dendritic cells induced by mouse 4-1BBL recombinant adenovirus. Yonsei Med J, 51: 594-598, 2010.

　　27.Kuang, Y., Zhu, H., Weng, X., Liu, X., Chen, Z., Chen, H., Jiang, B., and Zheng, Y. Antitumor immune response induced by DNA vaccine encoding human prostate-specific membrane antigen and mouse 4-1BBL. Urology, 76: 510-511, 2010.

　　28.Luo, H., Liu, X., Wu, T., and Zhang, X. Clinical application of percutaneous nephrostomy in some urologic diseases. J Huazhong Univ Sci Technolog Med Sci, 28: 439-442, 2008.

　　29.Xing, B., Chen, H., Zhang, M., Zhao, D., Jiang, R., Liu, X., and Zhang, S. Ischemic postconditioning inhibits apoptosis after focal cerebral ischemia/reperfusion injury in the rat. Stroke, 39: 2362-2369, 2008.

　　30.Chen, H., Xing, B., Liu, X., Zhan, B., Zhou, J., Zhu, H., and Chen, Z. Ozone oxidative preconditioning protects the rat kidney from reperfusion injury: the role of nitric oxide. J Surg Res, 149: 287-295, 2008.

　　31.Chen, H., Xing, B., Liu, X., Zhan, B., Zhou, J., Zhu, H., and Chen, Z. Ozone oxidative preconditioning inhibits inflammation and apoptosis in a rat model of renal ischemia/reperfusion injury. Eur J Pharmacol, 581: 306-314, 2008.

　　32.Chen, H., Xing, B., Liu, X., Zhan, B., Zhou, J., Zhu, H., and Chen, Z. Similarities between ozone oxidative preconditioning and ischemic preconditioning in renal ischemia/reperfusion injury. Arch Med Res, 39: 169-178, 2008.

　　33.Chen, H., Xing, B., Liu, X., Zhan, B., Zhou, J., Zhu, H., and Chen, Z. Ischemic postconditioning inhibits apoptosis after renal ischemia/reperfusion injury in rat. Transpl Int, 21: 364-371, 2008.

　　34.Xing, B., Chen, H., Zhang, M., Zhao, D., Jiang, R., Liu, X., and Zhang, S. Ischemic post-conditioning protects brain and reduces inflammation in a rat model of focal cerebral ischemia/reperfusion. J Neurochem, 105: 1737-1745, 2008.

　　35.Liu, X., Chen, H., Zhan, B., Xing, B., Zhou, J., Zhu, H., and Chen, Z. Attenuation of reperfusion injury by renal ischemic postconditioning: the role of NO. Biochem Biophys Res Commun, 359: 628-634, 2007.

　　36.Luo, H., Liu, X. and Lv, S. Neodymium:Yttrium Aluminum Garnet laser for mini-percutaneous treatment of upper urinary tract stones. J Huazhong Univ Sci Technolog Med Sci, 27: 197-199, 2007.

　　37.Hu, S., Liu, X. and Peng, Y. Assessment of antibiotic prescription in hospitalised patients at a Chinese university hospital. J Infect, 46: 161-163, 2003.